Erratum: Characterization of human kallikrein 6/prostease M expression in ovarian cancer
نویسندگان
چکیده
منابع مشابه
Differential expression of a human kallikrein 5 (KLK5) splice variant in ovarian and prostate cancer.
The presence of more than one mRNA form is common among kallikrein genes. We identified an mRNA transcript of the human kallikrein gene 5 (KLK5), denoted KLK5 splice variant 1 (KLK5-SV1). This variant has a different 5'-splice site, but encodes the same protein as the classical KLK5 transcript. RT-PCR analysis of this variant transcript expression in 29 human tissues indicated highest expressio...
متن کاملHigher human kallikrein gene 4 (KLK4) expression indicates poor prognosis of ovarian cancer patients.
PURPOSE Kallikrein gene 4 (KLK4, also known as prostase/KLK-L1), located on chromosome 19q13.4, is one of the newly discovered members of the human KLK-like gene family. This gene is up-regulated by androgens in the LNCaP prostatic carcinoma cell line and by androgens and progestins in the BT-474 breast cancer cell line. On the basis of its apparent association with hormonally regulated tissues...
متن کاملHuman kallikrein 6 (zyme/protease M/neurosin): a new serum biomarker of ovarian carcinoma.
BACKGROUND There is an urgent need for discovery and validation of new serum biomarkers for ovarian carcinoma. Early diagnosis of ovarian cancer with serologic analysis may improve clinical outcomes through administration of effective treatment. Human kallikrein 6 (hK6, encoded by the KLK6 gene) is a serine protease of the kallikrein gene family. Recently, we were able to develop an immunofluor...
متن کاملTargeting RAGE Expression in Human Ovarian Cancer
Receptor for Advanced Glycation Endproducts (RAGE) is expressed in ovarian tissue and associated with ovarian carcinoma. With a radiolabeled anti-RAGE antibody, we proposed to show extent of RAGE expression in animal model and effect of blocking RAGE on ovarian cancer cell growth. Methods: We measured inhibition of p-Akt and p-stat3 in SKOV-3 human ovarian carcinoma cell line and measured cell ...
متن کاملOvarian Cancer Parallel Overexpression of Seven Kallikrein Genes in
Recent evidence suggests that many members of the human kallikrein (KLK) gene family are differentially regulated in ovarian cancer and have potential as diagnostic and/or prognostic markers. We used the serial analysis of gene expression and expressed sequence tag databases of the Cancer Genome Anatomy Project to perform in silico analyses of the expression pattern of the 15 human KLK genes in...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2005
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6602508